Famotidine vs. Prilosec: 24-Hour Heartburn Med Showdown? In the crowded marketplace of heartburn remedies, two stars shine brightest: Famotidine and Prilosec. But don't let their names fool you-these aren't just synonyms for "acid reflux relief." They're two chefs in the same kitchen, each wielding a distinct recipe to calm the fire. Prilosec OTC (the brand name for Omeprazole Delayed Release Tablets) is the seasoned pro, known for its 24-hour acid-suppressing magic. As a proton pump inhibitor (PPI), it targets the root of the problem by silencing the stomach's acid-producing factories. Its 20mg tablets, neatly packaged in a 42-count box, offer long-lasting coverage, making it ideal for those who need nighttime relief or frequent heartburn management. Meanwhile, Famotidine (sold as Amazon Basic Care Maximum Strength Famotidine Tablets) plays the role of the quick-witted H2 blocker. It's a shorter-acting but no less effective contender, taking about 30 minutes to kick in and lasting up to 12 hours. Its 200-count pack is a budget-friendly powerhouse for daily use, though it might require a double dose for extended coverage. Then there's Gaviscon Extra Strength Cherry Chewable Tablets, the antacid with a twist. Acting like a trusty bouncer at a party, it forms a physical barrier over the stomach's contents, offering fast-acting relief with a playful, fruity flavor. While its 24-hour claims are hailed, it's more of a temporary fix than a daily solution. So, which one should you choose? It's less about the showdown and more about matching your needs to the right tool. PPIs like Prilosec are the heavyweights for chronic relief, H2 blockers like Famotidine are the efficient workers for midday comfort, and antacids like Gaviscon? They're the ice cubes in a hot drink-cooling fast, but fleeting. The real question isn't who wins, but who best fits your stomach's rhythm.