Xyzal vs. 24-Hour Allergy Relief, Tested Strength… Which Works Better This Season? We’ve been testing the waters this allergy season, and Xyzal Allergy Pills, 24-Hour Allergy Relief, 55-Count, Original Prescription Strength has certainly made headlines. While its original strength promises steady coverage, we’ve found the 24-hour formula to be reliable, though not without its quirks. Unlike some competitors that jack us up or leave us groggy, Xyzal delivers a balanced calm—enough to function but never overpowered. The 55-count size feels generous for long-term use at home, though we’d suggest rotating stocks if traveling. With seasonal shifts, we’re still weighing its effectiveness against others, but so far, Xyzal stands as a dependable option for those seeking targeted relief without jitters. Now, we’re curious how it stacks up against day-to-day rotational options.